The image below was shot in ISO3200 with Noise Filter set to Standard. With accurate exposure, the noise was well controlled. That's the trick. Nail the accurate exposure, and the shot will be fine. And thank goodness to E-3 accurate metering, this should not be a huge problem.
E-3 with Zuiko Digital ED50-200mm f2.8-3.5 SWD
200mm, f3.5, 1/30s, ISO3200
This image was captured at the beach of Jimbaran, Bali. Two ladies purchasing corn from the peddler. I was just sitting at the dinner table about 50 feet away. With the long reach of the 50-200mm lens, and E-3's super great Image Stabilization, all I needed was a few shots to get it right.
Click on the image for 2048 x 1536 size.